8WQ7

Crystal structure of d(CGTATACG)2 with a four-carbon linker containing diacridine compound

8WQ7 の概要

• エントリーDOI: 10.2210/pdb8wq7/pdb
• 分子名称: DNA (5'-D(P*CP*GP*TP*AP*TP*AP*CP*G)-3'), MANGANESE (II) ION, N,N'-di(acridin-9-yl)butane-1,4-diamine, ... (4 entities in total)
• 機能のキーワード: drug-dna complex, bis-intercalator, acridine, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 5405.66

構造登録者

Huang, S.C.,Satange, R.B.,Hou, M.H. (登録日: 2023-10-11, 公開日: 2024-08-07, 最終更新日: 2024-09-11)

• 主引用文献: Huang, S.C.,Chen, C.W.,Satange, R.,Hsieh, C.C.,Chang, C.C.,Wang, S.C.,Peng, C.L.,Chen, T.L.,Chiang, M.H.,Horng, Y.C.,Hou, M.H.; Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects.; Nucleic Acids Res., 52:9303-9316, 2024; PubMed: 39036959; DOI: 10.1093/nar/gkae643

実験手法

X-RAY DIFFRACTION (1.58 Å)