8WGT

Crystal structure of V30M-TTR in complex with compound 7

8WGT の概要

• エントリーDOI: 10.2210/pdb8wgt/pdb
• 分子名称: Transthyretin, [4,7-bis(chloranyl)-2-ethyl-1-benzofuran-3-yl]-[3,5-bis(iodanyl)-4-oxidanyl-phenyl]methanone (3 entities in total)
• 機能のキーワード: transthyretin, amyloidosis, inhibitor, benziodarone derivative, transport protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35859.11

構造登録者

Yokoyama, T. (登録日: 2023-09-22, 公開日: 2024-05-15, 最終更新日: 2024-05-29)

• 主引用文献: Mizuguchi, M.,Nakagawa, Y.,Yokoyama, T.,Okada, T.,Fujii, K.,Takahashi, K.,Luan, N.N.T.,Nabeshima, Y.,Kanamitsu, K.,Nakagawa, S.,Yamakawa, S.,Ueda, M.,Ando, Y.,Toyooka, N.; Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.; J.Med.Chem., 67:6987-7005, 2024; PubMed: 38670538; DOI: 10.1021/acs.jmedchem.3c02286

実験手法

X-RAY DIFFRACTION (1.696 Å)