8WGM

Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP

Summary for 8WGM

Entry DOI	10.2210/pdb8wgm/pdb
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	dhfr, dihydrofolate reductase, plasmodium falciparum, malaria, oxidoreductase
Biological source	Plasmodium falciparum VS/1
Total number of polymer chains	2
Total formula weight	146487.97
Authors	Vanichtanankul, J.,Saeyang, T.,Vitsupakorn, D.,Arwon, U.,Decharuangsilp, S.,Yuthavong, Y.,Kamchonwongpaisan, S. (deposition date: 2023-09-22, release date: 2024-09-11)
Primary citation	Decharuangsilp, S.,Arwon, U.,Hoarau, M.,Vanichtanankul, J.,Saeyang, T.,Jantra, T.,Rattanajak, R.,Thiabma, R.,Sooksai, N.,Kongkasuriyachai, D.,Kamchonwongpaisan, S.,Yuthavong, Y. Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors Bioorg.Chem., 2024 Cited by DOI: 10.1016/j.bioorg.2024.107789 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation