8WGM

Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP

8WGM の概要

• エントリーDOI: 10.2210/pdb8wgm/pdb
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dhfr, dihydrofolate reductase, plasmodium falciparum, malaria, oxidoreductase
• 由来する生物種: Plasmodium falciparum VS/1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 146487.97

構造登録者

Vanichtanankul, J.,Saeyang, T.,Vitsupakorn, D.,Arwon, U.,Decharuangsilp, S.,Yuthavong, Y.,Kamchonwongpaisan, S. (登録日: 2023-09-22, 公開日: 2024-09-11, 最終更新日: 2024-09-25)

• 主引用文献: Decharuangsilp, S.,Arwon, U.,Hoarau, M.,Vanichtanankul, J.,Saeyang, T.,Jantra, T.,Rattanajak, R.,Thiabma, R.,Sooksai, N.,Kongkasuriyachai, D.,Kamchonwongpaisan, S.,Yuthavong, Y.; Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors.; Bioorg.Chem., 153:107789-107789, 2024; PubMed: 39250850; DOI: 10.1016/j.bioorg.2024.107789

実験手法

X-RAY DIFFRACTION (2.15 Å)