8WE7
Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine at 3.2 Angstrom resolution
Summary for 8WE7
Entry DOI | 10.2210/pdb8we7/pdb |
EMDB information | 37473 |
Descriptor | Voltage-dependent L-type calcium channel subunit alpha-1C, 2-acetamido-2-deoxy-beta-D-glucopyranose, Voltage-dependent calcium channel subunit alpha-2/delta-1, ... (10 entities in total) |
Functional Keywords | cav1.2, channels, calcium ion-selective, transport protein, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 437456.52 |
Authors | |
Primary citation | Gao, S.,Yao, X.,Chen, J.,Huang, G.,Fan, X.,Xue, L.,Li, Z.,Wu, T.,Zheng, Y.,Huang, J.,Jin, X.,Wang, Y.,Wang, Z.,Yu, Y.,Liu, L.,Pan, X.,Song, C.,Yan, N. Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186:5363-5374.e16, 2023 Cited by PubMed: 37972591DOI: 10.1016/j.cell.2023.10.007 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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