8WDO
Crystal structure of PDE4D complexed with DCN
Summary for 8WDO
Entry DOI | 10.2210/pdb8wdo/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | pde4d, complex, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81307.20 |
Authors | |
Primary citation | Gu, C.,Liu, J.,Qian, F.,Yu, W.,Huang, D.,Shen, J.,Feng, C.,Chen, K.,Li, Y.,Jiang, X.,Xu, Y.,Zhang, L. Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model. J.Med.Chem., 67:4855-4869, 2024 Cited by PubMed: 38489246DOI: 10.1021/acs.jmedchem.3c02424 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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