8WDN

Crystal structure of PDE4D complexed with 7b-1

Summary for 8WDN

• Entry DOI: 10.2210/pdb8wdn/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: pde4d, complex, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 81425.37

Authors

Liu, J.Y.,Li, M.J.,Xu, Y.C. (deposition date: 2023-09-15, release date: 2024-08-28)

• Primary citation: Gu, C.,Liu, J.,Qian, F.,Yu, W.,Huang, D.,Shen, J.,Feng, C.,Chen, K.,Li, Y.,Jiang, X.,Xu, Y.,Zhang, L.; Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model.; J.Med.Chem., 67:4855-4869, 2024; PubMed: 38489246; DOI: 10.1021/acs.jmedchem.3c02424

Experimental method

X-RAY DIFFRACTION (1.55 Å)