8W8L

Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-38

Summary for 8W8L

• Entry DOI: 10.2210/pdb8w8l/pdb
• Descriptor: Proline--tRNA ligase, (2~{S})-~{N}-[5-(4-azanyl-8-fluoranyl-quinazolin-7-yl)-2-fluoranyl-phenyl]sulfonylpyrrolidine-2-carboxamide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: inhibitor, ligase
• Biological source: Pseudomonas aeruginosa 148
• Total number of polymer chains: 2
• Total formula weight: 130508.43

Authors

Luo, Z.,Zhou, H. (deposition date: 2023-09-03, release date: 2024-09-04)

• Primary citation: Luo, Z.,Zhou, H.; Structure-Guided Fluorine Scanning Accelerates the Discovery of Potent and Selective Inhibitors Against Bacterial Prolyl-tRNA Synthetase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.824 Å)