8W8L
Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-38
Summary for 8W8L
Entry DOI | 10.2210/pdb8w8l/pdb |
Descriptor | Proline--tRNA ligase, (2~{S})-~{N}-[5-(4-azanyl-8-fluoranyl-quinazolin-7-yl)-2-fluoranyl-phenyl]sulfonylpyrrolidine-2-carboxamide, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inhibitor, ligase |
Biological source | Pseudomonas aeruginosa 148 |
Total number of polymer chains | 2 |
Total formula weight | 130508.43 |
Authors | |
Primary citation | Luo, Z.,Zhou, H. Structure-Guided Fluorine Scanning Accelerates the Discovery of Potent and Selective Inhibitors Against Bacterial Prolyl-tRNA Synthetase To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.824 Å) |
Structure validation
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