8W8K

Crystal structures of HSP90 and the compound Ganetespid in the "closed" conformation

8W8K の概要

• エントリーDOI: 10.2210/pdb8w8k/pdb
• 分子名称: Heat shock protein HSP 90-alpha, 5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: hsp90, atpase, ntd, inhibitor, chaperone
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55428.22

構造登録者

Xu, C.,Zhang, X.L.,Bai, F. (登録日: 2023-09-03, 公開日: 2024-04-17, 最終更新日: 2024-05-08)

• 主引用文献: Xu, C.,Zhang, X.,Zhao, L.,Verkhivker, G.M.,Bai, F.; Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies.; Jacs Au, 4:1632-1645, 2024; PubMed: 38665669; DOI: 10.1021/jacsau.4c00123

実験手法

X-RAY DIFFRACTION (2.25 Å)