8W7W

Crystal structure of d(CGTATACG)2 with acridine complex

Summary for 8W7W

• Entry DOI: 10.2210/pdb8w7w/pdb
• Descriptor: DNA (5'-D(P*CP*GP*TP*AP*TP*AP*CP*G)-3'), ~{N},~{N}'-di(acridin-9-yl)pentane-1,5-diamine, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: drug-dna complex, bis-intercalator, acridine, dna
• Biological source: synthetic construct
• Total number of polymer chains: 4
• Total formula weight: 11581.40

Authors

Huang, S.C.,Satange, R.B.,Hou, M.H. (deposition date: 2023-08-31, release date: 2024-08-07, Last modification date: 2024-09-11)

• Primary citation: Huang, S.C.,Chen, C.W.,Satange, R.,Hsieh, C.C.,Chang, C.C.,Wang, S.C.,Peng, C.L.,Chen, T.L.,Chiang, M.H.,Horng, Y.C.,Hou, M.H.; Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects.; Nucleic Acids Res., 52:9303-9316, 2024; PubMed: 39036959; DOI: 10.1093/nar/gkae643

Experimental method

X-RAY DIFFRACTION (1.58 Å)