8W6R

murine SMPDL3A bound to sulfate

8W6R の概要

• エントリーDOI: 10.2210/pdb8w6r/pdb
• 分子名称: Acid sphingomyelinase-like phosphodiesterase 3a, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: innate immunity, lipid metabolism, hydrolase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48855.52

構造登録者

Zhang, C.,Liu, P.,Fan, S. (登録日: 2023-08-29, 公開日: 2023-12-20)

• 主引用文献: Hou, Y.,Wang, Z.,Liu, P.,Wei, X.,Zhang, Z.,Fan, S.,Zhang, L.,Han, F.,Song, Y.,Chu, L.,Zhang, C.; SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.; Immunity, 56:2492-2507.e10, 2023; PubMed: 37890481; DOI: 10.1016/j.immuni.2023.10.001

実験手法

X-RAY DIFFRACTION (1.95 Å)