8W45

X-ray crystal structure of V30M-TTR in complex with pinostilbene

8W45 の概要

• エントリーDOI: 10.2210/pdb8w45/pdb
• 分子名称: Transthyretin, 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: amyloidogenesis, thyroid hormone inhibitor, transport protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35215.68

構造登録者

Yokoyama, T. (登録日: 2023-08-23, 公開日: 2023-11-22, 最終更新日: 2023-12-06)

• 主引用文献: Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S.; Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.; J.Med.Chem., 66:15511-15523, 2023; PubMed: 37910439; DOI: 10.1021/acs.jmedchem.3c01698

実験手法

X-RAY DIFFRACTION (1.1 Å)