Summary for 8W3W
Entry DOI | 10.2210/pdb8w3w/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, 7-methoxy-1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}isoquinoline-6-carboxamide (3 entities in total) |
Functional Keywords | interleukin-1 receptor-associated kinase 4, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 147597.38 |
Authors | |
Primary citation | Wright, S.W.,Farley, K.A.,Han, S.,Knafels, J.D.,Lee, K.L. In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833). Acs Med.Chem.Lett., 15:540-545, 2024 Cited by PubMed: 38628800DOI: 10.1021/acsmedchemlett.4c00036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.976 Å) |
Structure validation
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