Summary for 8W0S
Entry DOI | 10.2210/pdb8w0s/pdb |
EMDB information | 43713 |
Descriptor | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, 1-methyl-8-[(oxan-4-yl)methyl]-3-[4-(trifluoromethyl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione (2 entities in total) |
Functional Keywords | emopamil-binding protein isomerization protein structure complex, structural protein, isomerase-inhibitor complex, isomerase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 55694.63 |
Authors | |
Primary citation | Dorel, R.,Sun, D.,Carruthers, N.,Castanedo, G.M.,Ung, P.M.,Factor, D.C.,Li, T.,Baumann, H.,Janota, D.,Pang, J.,Salphati, L.,Meklemburg, R.,Korman, A.J.,Harper, H.E.,Stubblefield, S.,Payandeh, J.,McHugh, D.,Lang, B.T.,Tesar, P.J.,Dere, E.,Masureel, M.,Adams, D.J.,Volgraf, M.,Braun, M.G. Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation. J.Med.Chem., 67:4819-4832, 2024 Cited by PubMed: 38470227DOI: 10.1021/acs.jmedchem.3c02396 PDB entries with the same primary citation |
Experimental method |
Structure validation
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