8VY4

Engineering a Tumor-Selective Prodrug T Cell Engager Bispecific Antibody for Safer Immunotherapy

Summary for 8VY4

• Entry DOI: 10.2210/pdb8vy4/pdb
• Descriptor: Fab Heavy Chain, Fab Light Chain, PCA-ASP-GLY-ASN-GLU-GLU-MET, ... (4 entities in total)
• Functional Keywords: antibody, cd3, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 3
• Total formula weight: 47675.87

Authors

Antonysamy, S.,Demarest, S.,Froning, K.,Hickey, M.H.,Kuhlman, B.,McCue, A.C. (deposition date: 2024-02-06, release date: 2024-07-24)

• Primary citation: McCue, A.C.,Demarest, S.J.,Froning, K.J.,Hickey, M.J.,Antonysamy, S.,Kuhlman, B.; Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy.; Mabs, 16:2373325-2373325, 2024; PubMed: 38962811; DOI: 10.1080/19420862.2024.2373325

Experimental method

X-RAY DIFFRACTION (1.7 Å)