8VXM

Human Bcl-2/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746

8VXM の概要

• エントリーDOI: 10.2210/pdb8vxm/pdb
• 関連するPDBエントリー: 8VWX 8VWZ 8VXN
• 分子名称: Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• 機能のキーワード: apoptosis, bcl-2, mbp fusion, bcl-xl chimera, s55746, complex, protein-protein interface inhibitor
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62077.75

構造登録者

Baird, J.,Holliday, M. (登録日: 2024-02-05, 公開日: 2024-10-02)

• 主引用文献: Sun, Y.,Houde, D.,Iacob, R.E.,Baird, J.,Swift, R.V.,Holliday, M.,Shi, X.,Sidoli, S.,Brenowitz, M.; Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics; To Be Published,

実験手法

X-RAY DIFFRACTION (2.1 Å)