8VWZ

Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746

Summary for 8VWZ

• Entry DOI: 10.2210/pdb8vwz/pdb
• Related: 8VWX 8VXM 8VXN
• Descriptor: Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: apoptosis, bcl-2, g101v mutant, mbp fusion, bcl-xl chimera, s55746, complex, protein-protein interface inhibitor
• Biological source: Escherichia coli K-12; More
• Total number of polymer chains: 1
• Total formula weight: 62119.83

Authors

Baird, J.,Holliday, M. (deposition date: 2024-02-02, release date: 2024-10-02)

• Primary citation: Sun, Y.,Houde, D.,Iacob, R.E.,Baird, J.,Swift, R.V.,Holliday, M.,Shi, X.,Sidoli, S.,Brenowitz, M.; Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.33 Å)