8VRP

HIV-CA Disulfide linked Hexamer bound to 4-Quinazolinone Scaffold inhibitor

これはPDB形式変換不可エントリーです。

8VRP の概要

• エントリーDOI: 10.2210/pdb8vrp/pdb
• 分子名称: Spacer peptide 1, N-[(1S)-1-[(3P,7M)-3-{4-chloro-3-[(ethanesulfonyl)amino]-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl}-7-(3-fluoro-4-formylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]-2-(3,5-difluorophenyl)ethyl]-2-[3-(trifluoromethyl)-5,6-dihydrocyclopenta[c]pyrazol-1(4H)-yl]acetamide, IODIDE ION, ... (4 entities in total)
• 機能のキーワード: hiv-1, human immunodeficiency virus, capsid, hiv-ca, capsid inhibitor, hiv restriction, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 79192.37

構造登録者

Goldstone, D.C.,Walsham, L. (登録日: 2024-01-22, 公開日: 2025-07-23)

• 主引用文献: Zhang, X.,Walsham, L.,Zhan, P.,Goldstone, D.C.; Discovery of 4-Quinazolinone-bearing Phenylalanine Derivatives as HIV-1 Capsid Inhibitors with Potent and Insensitivity Towards Clinically Relevant Resistant Mutations; To Be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)