8VRN

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ

This is a non-PDB format compatible entry.

Summary for 8VRN

• Entry DOI: 10.2210/pdb8vrn/pdb
• EMDB information: 43485
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-2, 3-(4-methylphenyl)-2-phenylquinazolin-4(3H)-one, PHOSPHATIDYLETHANOLAMINE, ... (13 entities in total)
• Functional Keywords: complex, pptq, drug modulation, gabaa receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 372566.16

Authors

Chojnacka, W.,Teng, J.,Kim, J.J.,Jensen, A.A.,Hibbs, R.E. (deposition date: 2024-01-22, release date: 2024-06-26, Last modification date: 2024-07-03)

• Primary citation: Chojnacka, W.,Teng, J.,Kim, J.J.,Jensen, A.A.,Hibbs, R.E.; Structural insights into GABA A receptor potentiation by Quaalude.; Nat Commun, 15:5244-5244, 2024; PubMed: 38898000; DOI: 10.1038/s41467-024-49471-y

Experimental method

ELECTRON MICROSCOPY (2.57 Å)