8VPN
Phosphorylated human NCC in complex with indapamide
Summary for 8VPN
Entry DOI | 10.2210/pdb8vpn/pdb |
EMDB information | 43411 |
Descriptor | Solute carrier family 12 member 3, 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | phosphorylation, a thiazide-like drug, indapamide, outward-open, transport protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 227869.56 |
Authors | |
Primary citation | Zhao, Y.,Schubert, H.,Blakely, A.,Forbush, B.,Smith, M.D.,Rinehart, J.,Cao, E. Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15:7006-7006, 2024 Cited by PubMed: 39143061DOI: 10.1038/s41467-024-51381-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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