8VKJ

Cryo-EM structure of human HGSNAT bound with Acetyl-CoA

8VKJ の概要

• エントリーDOI: 10.2210/pdb8vkj/pdb
• EMDBエントリー: 43319
• 分子名称: Heparan-alpha-glucosaminide N-acetyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: membrane protein, lysosome, transmembrane acetyltransferase, acetyl-coa, heperan sulfate
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 149879.66

構造登録者

Li, F.,Zhao, B. (登録日: 2024-01-09, 公開日: 2024-06-26, 最終更新日: 2024-10-16)

• 主引用文献: Zhao, B.,Cao, Z.,Zheng, Y.,Nguyen, P.,Bowen, A.,Edwards, R.H.,Stroud, R.M.,Zhou, Y.,Van Lookeren Campagne, M.,Li, F.; Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome.; Nat Commun, 15:5388-5388, 2024; PubMed: 38918376; DOI: 10.1038/s41467-024-49614-1

実験手法

ELECTRON MICROSCOPY (2.92 Å)