8VHB

Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate

Summary for 8VHB

Entry DOI	10.2210/pdb8vhb/pdb
Descriptor	Isocitrate dehydrogenase [NADP] cytoplasmic, 2-OXOGLUTARIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (10 entities in total)
Functional Keywords	oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	199578.74
Authors	Mealka, M.,Sohl, C.D.,Huxford, T. (deposition date: 2023-12-31, release date: 2024-04-24, Last modification date: 2024-05-22)
Primary citation	Mealka, M.,Sierra, N.A.,Avellaneda Matteo, D.,Albekioni, E.,Khoury, R.,Mai, T.,Conley, B.M.,Coleman, N.J.,Sabo, K.A.,Komives, E.A.,Bobkov, A.A.,Cooksy, A.L.,Silletti, S.,Schiffer, J.M.,Huxford, T.,Sohl, C.D. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun, 15:3785-3785, 2024 Cited by PubMed: 38710674 DOI: 10.1038/s41467-024-48277-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation