8VHB

Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate

8VHB の概要

• エントリーDOI: 10.2210/pdb8vhb/pdb
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, 2-OXOGLUTARIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (10 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 199578.74

構造登録者

Mealka, M.,Sohl, C.D.,Huxford, T. (登録日: 2023-12-31, 公開日: 2024-04-24, 最終更新日: 2024-05-22)

• 主引用文献: Mealka, M.,Sierra, N.A.,Avellaneda Matteo, D.,Albekioni, E.,Khoury, R.,Mai, T.,Conley, B.M.,Coleman, N.J.,Sabo, K.A.,Komives, E.A.,Bobkov, A.A.,Cooksy, A.L.,Silletti, S.,Schiffer, J.M.,Huxford, T.,Sohl, C.D.; Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.; Nat Commun, 15:3785-3785, 2024; PubMed: 38710674; DOI: 10.1038/s41467-024-48277-2

実験手法

X-RAY DIFFRACTION (1.89 Å)