8VHA
Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate
8VHA の概要
エントリーDOI | 10.2210/pdb8vha/pdb |
分子名称 | Isocitrate dehydrogenase [NADP] cytoplasmic, (3~{S})-3-[(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4~{H}-pyridin-4-yl]-2-oxidanylidene-pentanedioic acid, NITRATE ION, ... (8 entities in total) |
機能のキーワード | oxidoreductase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 197854.84 |
構造登録者 | |
主引用文献 | Mealka, M.,Sierra, N.A.,Avellaneda Matteo, D.,Albekioni, E.,Khoury, R.,Mai, T.,Conley, B.M.,Coleman, N.J.,Sabo, K.A.,Komives, E.A.,Bobkov, A.A.,Cooksy, A.L.,Silletti, S.,Schiffer, J.M.,Huxford, T.,Sohl, C.D. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun, 15:3785-3785, 2024 Cited by PubMed: 38710674DOI: 10.1038/s41467-024-48277-2 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.28 Å) |
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