8VH9

Crystal Structure of Human IDH1 R132Q in complex with NADPH

Summary for 8VH9

• Entry DOI: 10.2210/pdb8vh9/pdb
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 99143.67

Authors

Mealka, M.,Sohl, C.D.,Huxford, T. (deposition date: 2023-12-31, release date: 2024-04-24, Last modification date: 2024-05-22)

• Primary citation: Mealka, M.,Sierra, N.A.,Avellaneda Matteo, D.,Albekioni, E.,Khoury, R.,Mai, T.,Conley, B.M.,Coleman, N.J.,Sabo, K.A.,Komives, E.A.,Bobkov, A.A.,Cooksy, A.L.,Silletti, S.,Schiffer, J.M.,Huxford, T.,Sohl, C.D.; Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.; Nat Commun, 15:3785-3785, 2024; PubMed: 38710674; DOI: 10.1038/s41467-024-48277-2

Experimental method

X-RAY DIFFRACTION (2.13 Å)