8VBU

Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Oxacillin) inhibited form

8VBU の概要

• エントリーDOI: 10.2210/pdb8vbu/pdb
• 分子名称: Penicillin-binding protein 1, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid (3 entities in total)
• 機能のキーワード: penicillin binding protein 1, peptidoglycan transpeptidase domain, pedestal domain, membrane protein, hydrolase-inhibitor, antibiotic complex, hydrolase/inhibitor, antibiotic
• 由来する生物種: Staphylococcaceae bacterium
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 134095.42

構造登録者

Bon, C.G.,Lee, J.,Caveney, N.A.,Strynadka, N.C.J. (登録日: 2023-12-12, 公開日: 2024-05-01)

• 主引用文献: Bon, C.G.,Grigg, J.C.,Lee, J.,Robb, C.S.,Caveney, N.A.,Eltis, L.D.,Strynadka, N.C.J.; Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1.; J.Struct.Biol., 216:108086-108086, 2024; PubMed: 38527711; DOI: 10.1016/j.jsb.2024.108086

実験手法

X-RAY DIFFRACTION (2 Å)