8V9G

GES-5-meropenem complex

Summary for 8V9G

Entry DOI	10.2210/pdb8v9g/pdb
Descriptor	beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	class a beta-lactamase, carbapenemase, meropenem, antibiotic resistance, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	2
Total formula weight	63305.35
Authors	Smith, C.A.,Stewart, N.K.,Vakulenko, S.B. (deposition date: 2023-12-08, release date: 2024-04-03, Last modification date: 2024-04-24)
Primary citation	Stewart, N.K.,Toth, M.,Quan, P.,Beer, M.,Buynak, J.D.,Smith, C.A.,Vakulenko, S.B. Restricted Rotational Flexibility of the C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase. Acs Infect Dis., 10:1232-1249, 2024 Cited by PubMed: 38511828 DOI: 10.1021/acsinfecdis.3c00683 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation