8V9G
GES-5-meropenem complex
Summary for 8V9G
Entry DOI | 10.2210/pdb8v9g/pdb |
Descriptor | beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | class a beta-lactamase, carbapenemase, meropenem, antibiotic resistance, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 63305.35 |
Authors | Smith, C.A.,Stewart, N.K.,Vakulenko, S.B. (deposition date: 2023-12-08, release date: 2024-04-03, Last modification date: 2024-04-24) |
Primary citation | Stewart, N.K.,Toth, M.,Quan, P.,Beer, M.,Buynak, J.D.,Smith, C.A.,Vakulenko, S.B. Restricted Rotational Flexibility of the C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase. Acs Infect Dis., 10:1232-1249, 2024 Cited by PubMed: 38511828DOI: 10.1021/acsinfecdis.3c00683 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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