8V9B
Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732
This is a non-PDB format compatible entry.
Summary for 8V9B
Entry DOI | 10.2210/pdb8v9b/pdb |
Related | 8TCE |
Descriptor | Apolipoprotein(a), SULFATE ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | complex, inhibitor, ldl, lipid binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 23105.81 |
Authors | Hendle, J.,Weichert, K.,Sauder, J.M. (deposition date: 2023-12-07, release date: 2024-05-08, Last modification date: 2024-06-19) |
Primary citation | Diaz, N.,Perez, C.,Escribano, A.M.,Sanz, G.,Priego, J.,Lafuente, C.,Barberis, M.,Calle, L.,Espinosa, J.F.,Priest, B.T.,Zhang, H.Y.,Nosie, A.K.,Haas, J.V.,Cannady, E.,Borel, A.,Schultze, A.E.,Sauder, J.M.,Hendle, J.,Weichert, K.,Nicholls, S.J.,Michael, L.F. Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629:945-950, 2024 Cited by PubMed: 38720069DOI: 10.1038/s41586-024-07387-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.19 Å) |
Structure validation
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