8V6M

Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs

8V6M の概要

• エントリーDOI: 10.2210/pdb8v6m/pdb
• 関連するPDBエントリー: 8V6K 8V6L
• EMDBエントリー: 42994 42995 42996
• 分子名称: Transient receptor potential cation channel subfamily V member 3, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Tetrahydrocannabivarin, ... (4 entities in total)
• 機能のキーワード: transient receptor potential v family member 3, trp, channel, trpv3, trp channels, membrane protein, tetrahydrocannabivarin, thcv
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 381055.58

構造登録者

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (登録日: 2023-12-01, 公開日: 2024-04-17, 最終更新日: 2024-05-08)

• 主引用文献: Nadezhdin, K.D.,Neuberger, A.,Khosrof, L.S.,Talyzina, I.A.,Khau, J.,Yelshanskaya, M.V.,Sobolevsky, A.I.; TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.; Sci Adv, 10:eadn2453-eadn2453, 2024; PubMed: 38691614; DOI: 10.1126/sciadv.adn2453

実験手法

ELECTRON MICROSCOPY (3.63 Å)