8V6L
Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs
Summary for 8V6L
Entry DOI | 10.2210/pdb8v6l/pdb |
Related | 8V6K |
EMDB information | 42994 42995 |
Descriptor | Transient receptor potential cation channel subfamily V member 3, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Tetrahydrocannabivarin, ... (4 entities in total) |
Functional Keywords | transient receptor potential v family member 3, trp, channel, trpv3, trp channels, membrane protein, tetrahydrocannabivarin, thcv |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 387136.19 |
Authors | Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-12-01, release date: 2024-04-17, Last modification date: 2024-05-08) |
Primary citation | Nadezhdin, K.D.,Neuberger, A.,Khosrof, L.S.,Talyzina, I.A.,Khau, J.,Yelshanskaya, M.V.,Sobolevsky, A.I. TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Sci Adv, 10:eadn2453-eadn2453, 2024 Cited by PubMed: 38691614DOI: 10.1126/sciadv.adn2453 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.68 Å) |
Structure validation
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