8V6L

Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs

Summary for 8V6L

• Entry DOI: 10.2210/pdb8v6l/pdb
• Related: 8V6K
• EMDB information: 42994 42995
• Descriptor: Transient receptor potential cation channel subfamily V member 3, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Tetrahydrocannabivarin, ... (4 entities in total)
• Functional Keywords: transient receptor potential v family member 3, trp, channel, trpv3, trp channels, membrane protein, tetrahydrocannabivarin, thcv
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 387136.19

Authors

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-12-01, release date: 2024-04-17, Last modification date: 2024-05-08)

• Primary citation: Nadezhdin, K.D.,Neuberger, A.,Khosrof, L.S.,Talyzina, I.A.,Khau, J.,Yelshanskaya, M.V.,Sobolevsky, A.I.; TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.; Sci Adv, 10:eadn2453-eadn2453, 2024; PubMed: 38691614; DOI: 10.1126/sciadv.adn2453

Experimental method

ELECTRON MICROSCOPY (3.68 Å)