8V4H

X-ray structure of the NADP-dependent reductase from Campylobacter jejuni responsible for the synthesis of CDP-glucitol in the presence of CDP-glucitol

8V4H の概要

• エントリーDOI: 10.2210/pdb8v4h/pdb
• 関連するPDBエントリー: 5v4g
• 分子名称: Putative nucleotide sugar dehydratase, [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-2,3,4,5,6-pentakis(oxidanyl)hexyl] hydrogen phosphate, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: capsular polysaccharide, short chain dehydrogenase, oxidoreductase
• 由来する生物種: Campylobacter jejuni
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83512.10

構造登録者

Thoden, J.B.,Schumann, M.E.,Holden, H.M.,Raushel, F.M. (登録日: 2023-11-29, 公開日: 2023-12-20, 最終更新日: 2024-03-13)

• 主引用文献: Ghosh, M.K.,Narindoshvili, T.,Thoden, J.B.,Schumann, M.E.,Holden, H.M.,Raushel, F.M.; Biosynthesis of Cytidine Diphosphate-6-d-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni.; Biochemistry, 63:699-710, 2024; PubMed: 38386885; DOI: 10.1021/acs.biochem.3c00706

実験手法

X-RAY DIFFRACTION (2.2 Å)