8V1X

Crystal structure of polyketide synthase (PKS) thioreductase domain from Streptomyces coelicolor

Summary for 8V1X

• Entry DOI: 10.2210/pdb8v1x/pdb
• Descriptor: Type I polyketide synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: thioreductase domain, tr domain, polyketide synthases, pks, biosynthetic protein
• Biological source: Streptomyces coelicolor
• Total number of polymer chains: 2
• Total formula weight: 89592.80

Authors

Pereira, J.H.,Dan, Q.,Keasling, J.,Adams, P.D. (deposition date: 2023-11-21, release date: 2024-11-27, Last modification date: 2025-06-11)

• Primary citation: Dan, Q.,Chiu, Y.,Lee, N.,Pereira, J.H.,Rad, B.,Zhao, X.,Deng, K.,Rong, Y.,Zhan, C.,Chen, Y.,Cheong, S.,Li, C.,Gin, J.W.,Rodrigues, A.,Northen, T.R.,Backman, T.W.H.,Baidoo, E.E.K.,Petzold, C.J.,Adams, P.D.,Keasling, J.D.; A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids; Nat Catal, 8:147-161, 2025; DOI: 10.1038/s41929-025-01299-5

Experimental method

X-RAY DIFFRACTION (1.84 Å)