8V15

Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol

8V15 の概要

• エントリーDOI: 10.2210/pdb8v15/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, GLN-PRO-LYS-FDL, ZINC ION, ... (6 entities in total)
• 機能のキーワード: activator, complex, deacylase, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65801.87

構造登録者

Chakrabarti, R.,Ghosh, A.,Guan, X.,Upadhyay, A.,Dumpati, R.K.,Munshi, S.,Roy, S.,Chall, S.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T. (登録日: 2023-11-19, 公開日: 2023-12-06)

• 主引用文献: Chakrabarti, R.,Ghosh, A.,Guan, X.,Upadhyay, A.,Dumpati, R.K.,Munshi, S.,Roy, S.,Chall, S.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T.; Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion; biorxiv, 2023; DOI: 10.1101/2023.11.09.566481

実験手法

X-RAY DIFFRACTION (2.4 Å)