8V02

AaegOR10 structure bound to o-cresol

8V02 の概要

• エントリーDOI: 10.2210/pdb8v02/pdb
• EMDBエントリー: 42850
• 分子名称: Odorant receptor OR10, Odorant receptor Orco, o-cresol (3 entities in total)
• 機能のキーワード: mosquito olfactory receptor or10, membrane protein
• 由来する生物種: Aedes aegypti (yellow fever mosquito); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 203214.17

構造登録者

Zhao, J.,del Marmol, J. (登録日: 2023-11-16, 公開日: 2024-06-19, 最終更新日: 2024-07-10)

主引用文献

Zhao, J.,Chen, A.Q.,Ryu, J.,Del Marmol, J.
Structural basis of odor sensing by insect heteromeric odorant receptors.
Science, 384:1460-1467, 2024

PubMed Abstract: Most insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo-electron microscopy structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos or . These structures reveal an unexpected stoichiometry of one OR to three Orco subunits. Comparison of structures in odorant-bound and unbound states indicates that odorant binding to the sole OR subunit is sufficient to open the channel pore, suggesting a mechanism of OR activation and a conceptual framework for understanding evolution of insect odorant receptor sensitivity.

PubMed: 38870275
DOI: 10.1126/science.adn6384

実験手法

ELECTRON MICROSCOPY (2.9 Å)