8UZC

Structure of UT14 Fab in complex with the head domain of H3 (A/Singapore/INFIMH-16-0019/2016)

Summary for 8UZC

• Entry DOI: 10.2210/pdb8uzc/pdb
• EMDB information: 42839
• Descriptor: UT14 Fab heavy chain, UT14 Fab light chain, Hemagglutinin (3 entities in total)
• Functional Keywords: complex, viral protein, immune system, influenza, hemagglutinin
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 113648.15

Authors

Park, J.,Georgiou, G. (deposition date: 2023-11-14, release date: 2024-11-27, Last modification date: 2025-03-05)

Primary citation

Park, J.,Bartzoka, F.,von Beck, T.,Li, Z.N.,Mishina, M.,Hebert, L.S.,Kain, J.,Liu, F.,Sharma, S.,Cao, W.,Eddins, D.J.,Kumar, A.,Kim, J.E.,Lee, J.S.,Wang, Y.,Schwartz, E.A.,Brilot, A.F.,Satterwhite, E.,Towers, D.M.,McKnight, E.,Pohl, J.,Thompson, M.G.,Gaglani, M.,Dawood, F.S.,Naleway, A.L.,Stevens, J.,Kennedy, R.B.,Jacob, J.,Lavinder, J.J.,Levine, M.Z.,Gangappa, S.,Ippolito, G.C.,Sambhara, S.,Georgiou, G.
Molecular features of the serological IgG repertoire elicited by egg-based, cell-based, or recombinant haemagglutinin-based seasonal influenza vaccines: a comparative, prospective, observational cohort study.
Lancet Microbe, 6:100935-100935, 2025

PubMed Abstract: Egg-based inactivated quadrivalent seasonal influenza vaccine (eIIV4), cell culture-based inactivated quadrivalent seasonal influenza vaccine (ccIIV4), and recombinant haemagglutinin (HA)-based quadrivalent seasonal influenza vaccine (RIV4) have been licensed for use in the USA. In this study, we used antigen-specific serum proteomics analysis to assess how the molecular composition and qualities of the serological antibody repertoires differ after seasonal influenza immunisation by each of the three vaccines and how different vaccination platforms affect the HA binding affinity and breadth of the serum antibodies that comprise the polyclonal response.

PubMed: 39667375
DOI: 10.1016/j.lanmic.2024.06.002

Experimental method

ELECTRON MICROSCOPY (3.8 Å)