8UXH
Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium
This is a non-PDB format compatible entry.
Summary for 8UXH
Entry DOI | 10.2210/pdb8uxh/pdb |
EMDB information | 42764 |
Descriptor | Ryanodine receptor 2, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION, ... (5 entities in total) |
Functional Keywords | calcium channel, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 2312933.90 |
Authors | Miotto, M.C.,Marks, A.R. (deposition date: 2023-11-09, release date: 2023-11-22, Last modification date: 2024-10-02) |
Primary citation | Miotto, M.C.,Reiken, S.,Wronska, A.,Yuan, Q.,Dridi, H.,Liu, Y.,Weninger, G.,Tchagou, C.,Marks, A.R. Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nat Commun, 15:8080-8080, 2024 Cited by PubMed: 39278969DOI: 10.1038/s41467-024-51791-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.52 Å) |
Structure validation
Download full validation report