8UVR
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution
これはPDB形式変換不可エントリーです。
8UVR の概要
エントリーDOI | 10.2210/pdb8uvr/pdb |
分子名称 | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
機能のキーワード | spectinomycin; aminomethyl spectinomycin; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; infectious diseases; antimicrobial drug discovery; semisynthetic chemistry; drug development, ribosome, ribosome-inhibitor, antibiotic complex, ribosome/inhibitor, antibiotic |
由来する生物種 | Escherichia coli 詳細 |
タンパク質・核酸の鎖数 | 112 |
化学式量合計 | 4571730.53 |
構造登録者 | |
主引用文献 | Phelps, G.A.,Cheramie, M.N.,Fernando, D.M.,Selchow, P.,Meyer, C.J.,Waidyarachchi, S.L.,Dharuman, S.,Liu, J.,Meuli, M.,Molin, M.D.,Killam, B.Y.,Murphy, P.A.,Reeve, S.M.,Wilt, L.A.,Anderson, S.M.,Yang, L.,Lee, R.B.,Temrikar, Z.H.,Lukka, P.B.,Meibohm, B.,Polikanov, Y.S.,Hobbie, S.N.,Bottger, E.C.,Sander, P.,Lee, R.E. Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus. Proc.Natl.Acad.Sci.USA, 121:e2314101120-e2314101120, 2024 Cited by PubMed: 38165935DOI: 10.1073/pnas.2314101120 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
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