8UPB

De novo designed IL-6 mimetic

Summary for 8UPB

Entry DOI	10.2210/pdb8upb/pdb
Descriptor	De novo designed IL-6 mimetic (2 entities in total)
Functional Keywords	cytokine, de novo design
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	7826.06
Authors	Borowska, M.T.,Jude, K.M.,Garcia, K.C. (deposition date: 2023-10-22, release date: 2024-08-28)
Primary citation	Huang, B.,Coventry, B.,Borowska, M.T.,Arhontoulis, D.C.,Exposit, M.,Abedi, M.,Jude, K.M.,Halabiya, S.F.,Allen, A.,Cordray, C.,Goreshnik, I.,Ahlrichs, M.,Chan, S.,Tunggal, H.,DeWitt, M.,Hyams, N.,Carter, L.,Stewart, L.,Fuller, D.H.,Mei, Y.,Garcia, K.C.,Baker, D. De novo design of miniprotein antagonists of cytokine storm inducers. Nat Commun, 15:7064-7064, 2024 Cited by PubMed: 39152100 DOI: 10.1038/s41467-024-50919-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation