8UOA

Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody

Summary for 8UOA

• Entry DOI: 10.2210/pdb8uoa/pdb
• EMDB information: 42432
• Descriptor: Synaptic vesicle glycoprotein 2A, Nanobody, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: synaptic vesicle, slc22, inhibitor, nanobody, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 92493.63

Authors

Mittal, A.,Martin, M.F.,Levin, E.,Adams, C.,Yang, M.,Ledecq, M.,Horanyi, P.S.,Coleman, J.A. (deposition date: 2023-10-19, release date: 2024-05-22, Last modification date: 2024-06-26)

• Primary citation: Mittal, A.,Martin, M.F.,Levin, E.J.,Adams, C.,Yang, M.,Provins, L.,Hall, A.,Procter, M.,Ledecq, M.,Hillisch, A.,Wolff, C.,Gillard, M.,Horanyi, P.S.,Coleman, J.A.; Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.; Nat.Struct.Mol.Biol., 2024; PubMed: 38898101; DOI: 10.1038/s41594-024-01335-1

Experimental method

ELECTRON MICROSCOPY (3.8 Å)