8UK6

Candida albicans glutaminyl tRNA synthetase (GLN4) in complex with N-pyrimidinyl-beta-thiophenylacrylamide

8UK6 の概要

• エントリーDOI: 10.2210/pdb8uk6/pdb
• 分子名称: glutamine--tRNA ligase, ZINC ION, (2E)-N-(pyrimidin-2-yl)-3-(thiophen-2-yl)prop-2-enamide, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, allosteric, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Candida albicans
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 93783.95

構造登録者

Sychantha, D.,Wright, G.D. (登録日: 2023-10-12, 公開日: 2024-03-06, 最終更新日: 2024-05-01)

• 主引用文献: Puumala, E.,Sychantha, D.,Lach, E.,Reeves, S.,Nabeela, S.,Fogal, M.,Nigam, A.,Johnson, J.W.,Aspuru-Guzik, A.,Shapiro, R.S.,Uppuluri, P.,Kalyaanamoorthy, S.,Magolan, J.,Whitesell, L.,Robbins, N.,Wright, G.D.,Cowen, L.E.; Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-beta-thiophenylacrylamides exerts highly selective antifungal activity.; Cell Chem Biol, 31:760-, 2024; PubMed: 38402621; DOI: 10.1016/j.chembiol.2024.01.010

実験手法

X-RAY DIFFRACTION (2.73 Å)