8UGV

Crystal structure of the second bromodomain of human BRD2 in complex with 6IND

Summary for 8UGV

• Entry DOI: 10.2210/pdb8ugv/pdb
• Related: 8UGU
• Descriptor: Bromodomain-containing protein 2, methyl [(4S,6P,10aM)-6-(1H-indol-6-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate (3 entities in total)
• Functional Keywords: brd2, bromodomain, bromodomain inhibitor, transcription factor, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 27879.84

Authors

Nithianantham, S.,Fischer, M. (deposition date: 2023-10-06, release date: 2025-04-02)

• Primary citation: Chowdhury, N.,Nithianantham, S.,Lang, W.,Young, S.,Philips, S.,Das, S.,Shelat, A.,Fischer, M.,Ansari, A.,Jaisankar, P.; Development of synthetic molecules for bromodomain-selective recruitment of transcriptional regulators to targeted genomic loci; to be published,

Experimental method

X-RAY DIFFRACTION (1.99 Å)