8U6O

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with5-(2-(3-oxo-3-(pyrrolidin-1-yl)propoxy)phenoxy)-2-naphthonitrile (JLJ753), a non-nucleoside inhibitor

Summary for 8U6O

• Entry DOI: 10.2210/pdb8u6o/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 5-{2-[3-oxo-3-(pyrrolidin-1-yl)propoxy]phenoxy}naphthalene-2-carbonitrile, ... (4 entities in total)
• Functional Keywords: reverse transcriptase, antiviral, drug design, hiv-1, viral protein
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10); More
• Total number of polymer chains: 2
• Total formula weight: 114358.11

Authors

Prucha, G.,Henry, S.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-09-13, release date: 2023-11-08)

• Primary citation: Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S.; Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase.; Eur.J.Med.Chem., 262:115894-115894, 2023; PubMed: 37883896; DOI: 10.1016/j.ejmech.2023.115894

Experimental method

X-RAY DIFFRACTION (2.48 Å)