8U6K

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(2-((6-cyanonaphthalen-1-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ747), a non-nucleoside inhibitor

8U6K の概要

• エントリーDOI: 10.2210/pdb8u6k/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, N-(2-{2-[(6-cyanonaphthalen-1-yl)oxy]phenoxy}ethyl)-N-methylprop-2-enamide, ... (6 entities in total)
• 機能のキーワード: reverse transcriptase, antiviral, drug design, hiv-1, viral protein
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114544.72

構造登録者

Prucha, G.,Henry, S.,Jorgensen, W.L.,Anderson, K.S. (登録日: 2023-09-13, 公開日: 2023-11-08)

• 主引用文献: Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S.; Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase.; Eur.J.Med.Chem., 262:115894-115894, 2023; PubMed: 37883896; DOI: 10.1016/j.ejmech.2023.115894

実験手法

X-RAY DIFFRACTION (2.72 Å)