8U1X
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Summary for 8U1X
Entry DOI | 10.2210/pdb8u1x/pdb |
EMDB information | 41837 |
Descriptor | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (4 entities in total) |
Functional Keywords | complex, phosphatase, cell cycle |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 171214.11 |
Authors | |
Primary citation | Wu, C.G.,Balakrishnan, V.K.,Merrill, R.A.,Parihar, P.S.,Konovolov, K.,Chen, Y.C.,Xu, Z.,Wei, H.,Sundaresan, R.,Cui, Q.,Wadzinski, B.E.,Swingle, M.R.,Musiyenko, A.,Chung, W.K.,Honkanen, R.E.,Suzuki, A.,Huang, X.,Strack, S.,Xing, Y. B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121:e2310727120-e2310727120, 2024 Cited by PubMed: 38150499DOI: 10.1073/pnas.2310727120 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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