8U1D

Cryo-EM structure of vaccine-elicited CD4 binding site antibody DH1285 bound to HIV-1 CH505TFchim.6R.SOSIP.664v4.1 Env Local Refinement

8U1D の概要

• エントリーDOI: 10.2210/pdb8u1d/pdb
• EMDBエントリー: 41810
• 分子名称: Envelope glycoprotein gp120, DH1285 Heavy Chain, DH1285 Light Chain, ... (4 entities in total)
• 機能のキーワード: hiv-1 vaccine induced neutralizing antibody, cd4 binding site antibody, gp120, dh1285, igg, rhesus macaques, ch505m5chimer.6r.sosip.664v4.1 env, viral protein
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 124527.56

構造登録者

Thakur, B.,Stalls, V.D.,Acharya, P. (登録日: 2023-08-31, 公開日: 2024-01-03, 最終更新日: 2024-07-17)

• 主引用文献: Saunders, K.O.,Counts, J.,Thakur, B.,Stalls, V.,Edwards, R.,Manne, K.,Lu, X.,Mansouri, K.,Chen, Y.,Parks, R.,Barr, M.,Sutherland, L.,Bal, J.,Havill, N.,Chen, H.,Machiele, E.,Jamieson, N.,Hora, B.,Kopp, M.,Janowska, K.,Anasti, K.,Jiang, C.,Van Itallie, E.,Venkatayogi, S.,Eaton, A.,Henderson, R.,Barbosa, C.,Alam, S.M.,Santra, S.,Weissman, D.,Moody, M.A.,Cain, D.W.,Tam, Y.K.,Lewis, M.,Williams, W.B.,Wiehe, K.,Montefiori, D.C.,Acharya, P.,Haynes, B.F.; Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.; Cell, 187:79-94.e24, 2024; PubMed: 38181743; DOI: 10.1016/j.cell.2023.12.002

実験手法

ELECTRON MICROSCOPY (4.25 Å)