8TXH

Crystal structure of KRAS G12D in complex with GDP and compound 14

8TXH の概要

• エントリーDOI: 10.2210/pdb8txh/pdb
• 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: molecule, gtpase, kras, inhibitor, oncoprotein, oncoprotein-inhibitor complex, oncoprotein/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41056.06

構造登録者

Chen, P.,Irimia, A.,Yang, Z. (登録日: 2023-08-23, 公開日: 2023-11-08)

• 主引用文献: Cheng, H.,Li, P.,Chen, P.,Irimia, A.,Bae, J.H.,Brooun, A.,Fagan, P.,Lam, R.,Lin, B.,Zhang, J.,Zhan, X.,Wu, X.,Xie, N.,Chiang, G.,Shoemaker, R.,Vernier, J.M.; Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.; Acs Med.Chem.Lett., 14:1351-1357, 2023; PubMed: 37849557; DOI: 10.1021/acsmedchemlett.3c00245

実験手法

X-RAY DIFFRACTION (1.2 Å)