8TWY
Structure of PIK3CA with covalent inhibitor ALO26
Summary for 8TWY
Entry DOI | 10.2210/pdb8twy/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 1-(4-{[2-(4-{(4P)-4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethoxy]methyl}piperidin-1-yl)prop-2-en-1-one (2 entities in total) |
Functional Keywords | pi3k, pik3ca, lipid kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 110586.82 |
Authors | Burke, J.E.,Barlow-Busch, I. (deposition date: 2023-08-21, release date: 2024-08-28, Last modification date: 2024-10-16) |
Primary citation | Burke, J.E.,Barlow-Busch, I. Structure of PIK3CA with covalent inhibitor ALO26 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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